That taurine egress is dependent on specific ions suggests that it is not purely passive diffusion, but probably involves a carrier-facilitated process. Efflux is much slower than uptake and has a higher K m. It does not contribute to the renal adaptive response described below. Taurine efflux from renal cells is dependent on the intracellular taurine concentration and requires the presence of both Na + and Cl - in the system. In a proximal tubule cell line (LLC-PK1), uptake is maximal on the apical surface in a distal tubule cell line (MDCK), uptake occurs at the basolateral surface (Figure 2). Taurine transport is stereospecific, inhibited by other ß-amino acids and GABA (gamma-aminobutyric acid) but not by α-amino acids, and is membrane surface-specific. Sodium and chloride move into cells by means of an external to internal downhill Na + gradient (a chemical gradient), and then the sodium is pumped out of the cell by Na +K +-dependent ATPase. The model that best describes this transport is 2 Na +:1 taurine:1 Cl - (Figure 1). In addition to sodium, taurine uptake by renal epithelia requires chloride or bromide. The active uphill transport of taurine occurs via a sodium-dependent transporter (TauT). Some of these properties lead to the role of conjugation of bile acids and uridine in tRNA. It has the lowest pK 1 and pK 2 of all amino acids. Its accumulation within the cell requires active transport from the extracellular environment, where it is found in only micromolar quantities. The taurine molecule acts as a zwitterion at physiologic pH and resides within the cell in millimolar quantities. Taurine is not incorporated into protein, and can serve as an intracellular osmolyte. It is readily soluble in aqueous solutions. The physiochemical properties of the ß-amino acid taurine are probably responsible for some of its biologic characteristics. In addition, the role of taurine in the pathophysiology of kidney disease will be examined. Thus, this review will focus on several aspects of renal function in relation to taurine and will cover large biologic themes. The numerous physiologic regulators of taurine handling by the kidney have been recently reviewed. Taurine participates in several biologic processes in the kidney, and the kidney influences specific aspects of taurine homeostasis. With sweetener.The interactions between the kidney and taurine are many and varied. Magnesium citrate, magnesium * Guanylor ® (sodium guanylate, sodium inosinate, yeast extract, magnesium chloride), natural lemon flavor, acidifying: citric acid and malic acid, taurine, sweetener sucralose, vitamin B6. This dietary supplement can not replace a varied alimentationo, balanced and healthy life. Vitamin B6 is essential to synthesize taurine (precursor).ĭilute 1 stick per day in a glass of water for 20 days.ĭo not exceed the recommended daily dose. It improves the intracellular incorporation of magnesium and reduces cell excitation. Taurine is a sulfur-containing amino acid derivative, cysteine. This ingredient, the production process is protected by a patent, is interesting for minerals with low intestinal absorption, such as iron or magnesium for example. This is developed by PiLeJe ingredient to facilitate the passage of minerals through the intestinal barrier.
The intake of magnesium is provided as Guanylor ®ĪSTEMAG is recommended in acute magnesium deficiency.ĪSTEMAG is based Guanylor ®.
PILEJE ASTEMAG 20 STICKS OF 4 GR Magnesium Taurine Vit B6ĪSTEMAG PiLeJe laboratory, which is a dietary supplement, providing magnesium, taurine and vitamin B6 is involved in neuromuscular relaxation.ĪSTEMAG optimizes assimilation and fixation of magnesium in the body.
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